Artificial intelligence holds great promise in medical imaging, especially histopathological imaging. However, artificial intelligence algorithms cannot fully explain the thought processes during decision-making. This situation has brought the problem of explainability, i.e., the black box problem, of artificial intelligence applications to the agenda: an algorithm simply responds without stating the reasons for the given images. To overcome the problem and improve the explainability, explainable artificial intelligence (XAI) has come to the fore, and piqued the interest of many researchers. Against this backdrop, this study examines a new and original dataset using the deep learning algorithm, and visualizes the output with gradient-weighted class activation mapping (Grad-CAM), one of the XAI applications. Afterwards, a detailed questionnaire survey was conducted with the pathologists on these images. Both the decision-making processes and the explanations were verified, and the accuracy of the output was tested. The research results greatly help pathologists in the diagnosis of paratuberculosis.

Precise and reliable estimation of reference evapotranspiration (ET o ) is an essential for the irrigation and water resources management. ET o is difficult to predict due to its complex processes. This complexity can be solved using machine learning methods. This study investigates the performance of artificial neural network (ANN) and deep neural network (DNN) models for estimating daily ET o . Previously proposed ANN and DNN methods have been realized, and their performances have been compared. Six input data including maximum air temperature (T max ), minimum air temperature (T min ), solar radiation (R n ), maximum relative humidity (RH max ), minimum relative humidity (RH min ) and wind speed (U 2 ) are used from 4 meteorological stations (Adana, Aksaray, Isparta and Ni\u{g}de) during 1999-2018 in Turkey. The results have shown that our proposed DNN models achieves satisfactory accuracy for daily ET o estimation compared to previous ANN and DNN models. The best performance has been observed with the proposed model of DNN with SeLU activation function (P-DNN-SeLU) in Aksaray with coefficient of determination (R 2 ) of 0.9934, root mean square error (RMSE) of 0.2073 and mean absolute error (MAE) of 0.1590, respectively. Therefore, the P-DNN-SeLU model could be recommended for estimation of ET o in other climate zones of the world.